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Both were approved in the U.S

Additionally, conducting preclinical and clinical studies is crucial to evaluate safety, pharmacokinetics, and therapeutic outcomes in diverse patient populations

In weight loss clinical trials, semaglutide helped people lose about 15 percent of their body weight on average significantly more than the currently available obesity drugs and more than enough to improve health outcomes

In contrast, alternative materials such as allografts and xenografts for bone defect repair carry potential risks including antigenicity, pathogen transmission, immune rejection and graft resorption (Sivakumar et al., 2022